Lorry Frankel

Clinical Focus

• Intensive Care, Pediatric
• Pediatric Critical Care Medicine

Professional Education

• Board Certification: Pediatric Critical Care Medicine, American Board of Pediatrics (1990)
• Board Certification: General Pediatrics, American Board of Pediatrics (1983)
• Childrens Hospital-San Diego (1983) CA
• Valley Medical Center-Fresno (1982) CA
• Valley Medical Center-Fresno (1981) CA
• Blank Childrens Hospital (1979) IA
• University of Antwerp (1978) Belgium

Research Interests

I conduct clinical studies into the cases of children with RSV bronchiolitis. In addition, I collaborate with Dr. Dale Umetsu in the evaluation of alveolar macrophage behavior and presentation of antigen.


Additional publication:

The Pediatric Intensive Care Unit for the Medical Student in Textbook of Pediatrics for Medical Students, Bernstein D. and Shelov S. eds. January, 1996.

Kim K, Frankel LR, The need for inotropic support in a subgroup of infants with severe life-threatening respiratory syncitial viral infection, J. Investig Med 1997;45:1-5.

Frankel, LR, Ford R, Der Yeghiaian M, The role for ECMO combined with aggressive fiberopitc bronchoscpy in 2 infants with severe pertusis pneumonia, in preparation.

Andrus J, Frankel LR, Ford R, et al: bronchopleural fistula (BPF) treated with asychronous lung ventilation, in preaparation.

Clinical Trials

• Pilot Study to Evaluate a Method of Controlling High Blood Sugar in the Pediatric Intensive Care Unit Completed

Publications

• Improving communication in a pediatric intensive care unit using daily patient goal sheets. Agarwal S,  Frankel L, Tourner S, McMillan A, Sharek PJ.  J Crit Care.  2008; 23 (2): 227-35
• Effect of a rapid response team on hospital-wide mortality and code rates outside the ICU in a Children's Hospital. Sharek PJ,  Parast LM, Leong K, Coombs J, Earnest K, Sullivan J, Frankel LR, Roth SJ.  JAMA.  2007; 298 (19): 2267-74
• The hemophagocytic syndrome: titrating continuous hemofiltration to the degree of lactic acidosis. DiCarlo J,  Lui WY, Frankel L, Howell W, Schiffman J, Alexander S.  Pediatr Hematol Oncol.  2006 Oct-Nov; 23 (7): 599-610
• Food, toys, and love: pediatric palliative care. Sourkes B,  Frankel L, Brown M, Contro N, Benitz W, Case C, Good J, Jones L, Komejan J, Modderman-Marshall J, Reichard W, Sentivany-Collins S, Sunde C.  Curr Probl Pediatr Adolesc Health Care.  2005; 35 (9): 350-86
• Identification of Epstein-Barr virus-specific CD8+ T lymphocytes in the circulation of pediatric transplant recipients. Falco DA,  Nepomuceno RR, Krams SM, Lee PP, Davis MM, Salvatierra O, Alexander SR, Esquivel CO, Cox KL, Frankel LR, Martinez OM.  Transplantation.  2002; 74 (4): 501-10
• Human alveolar macrophages induce functional inactivation in antigen-specific CD4 T cells. Blumenthal RL,  Campbell DE, Hwang P, DeKruyff RH, Frankel LR, Umetsu DT.  J Allergy Clin Immunol.  2001; 107 (2): 258-64
• Group A streptococcal meningitis: report of a case and review of literature since 1976. Shetty AK,  Frankel LR, Maldonado Y, Falco DA, Lewis DB.  Pediatr Emerg Care.  2001; 17 (6): 430-4
• Mechanical ventilation for pediatric patients. Hammer GB,  Frankel LR.  Int Anesthesiol Clin.  1997; 35 (1): 139-67
• The need for inotropic support in a subgroup of infants with severe life-threatening respiratory syncytial viral infection. Kim KK,  Frankel LR.  J Investig Med.  1997; 45 (8): 469-73
• Identifying early predictors of mortality in pediatric patients with acute leukemia and pneumonia. Randle CJ,  Frankel LR, Amylon MD.  Chest.  1996; 109 (2): 457-61
• Venous catheter thrombus formation and pulmonary embolism in children. Derish MT,  Smith DW, Frankel LR.  Pediatr Pulmonol.  1995; 20 (6): 349-54
• Cardiac transplantation for hypertrophic cardiomyopathy associated with Sengers syndrome. Robbins RC,  Bernstein D, Berry GJ, VanMeurs KP, Frankel LR, Reitz BA.  Ann Thorac Surg.  1995; 60 (5): 1425-7
• Human alveolar macrophages present antigen ineffectively due to defective expression of B7 costimulatory cell surface molecules. Chelen CJ,  Fang Y, Freeman GJ, Secrist H, Marshall JD, Hwang PT, Frankel LR, DeKruyff RH, Umetsu DT.  J Clin Invest.  1995; 95 (3): 1415-21
• Frequency and prognostic significance of HRX rearrangements in infant acute lymphoblastic leukemia: a Pediatric Oncology Group study. Rubnitz JE,  Link MP, Shuster JJ, Carroll AJ, Hakami N, Frankel LS, Pullen DJ, Cleary ML.  Blood.  1994; 84 (2): 570-3
• High-frequency jet ventilation in children with the adult respiratory distress syndrome complicated by pulmonary barotrauma. Smith DW,  Frankel LR, Derish MT, Moody RR, Black LE, Chipps BE, Mathers LH.  Pediatr Pulmonol.  1993; 15 (5): 279-86
• Value of bronchoalveolar lavage in diagnosing severe respiratory syncytial virus infections in infants. Derish MT,  Kulhanjian JA, Frankel LR, Smith DW.  J Pediatr.  1991; 119 (5): 761-3
• A controlled trial of aerosolized ribavirin in infants receiving mechanical ventilation for severe respiratory syncytial virus infection. Smith DW,  Frankel LR, Mathers LH, Tang AT, Ariagno RL, Prober CG.  N Engl J Med.  1991; 325 (1): 24-9
• Pulmonary function testing in infants with respiratory syncytial virus bronchiolitis requiring mechanical ventilation. Smith DW,  Rector DM, Derish MT, Frankel LR, Ariagno RL.  Pediatr Infect Dis J.  1990; 9 (9 Suppl): S108-11
• Severe metabolic acidosis after acute naproxen sodium ingestion. Martinez R,  Smith DW, Frankel LR.  Ann Emerg Med.  1989; 18 (10): 1102-4
• Dissociation of mean airway pressure and lung volume during high-frequency oscillatory ventilation. Smith DW,  Frankel LR, Ariagno RL.  Crit Care Med.  1988; 16 (5): 531-5
• Retinal folds in the shaken baby syndrome. Gaynon MW,  Koh K, Marmor MF, Frankel LR.  Am J Ophthalmol.  1988; 106 (4): 423-5
• Bronchoalveolar lavage for diagnosis of pneumonia in the immunocompromised child. Frankel LR,  Smith DW, Lewiston NJ.  Pediatrics.  1988; 81 (6): 785-8
• Rapid assessment of ventilation by measurement of carbon dioxide elimination during high-frequency ventilation of kittens. Smith DW,  Frankel LR, Walker JG, Cheng EY, Meredith KS, Mihm FG, Ariagno RL.  Pediatr Pulmonol.  1987 Nov-Dec; 3 (6): 406-12
• Immediate management of the asphyxiated infant: facilitating the cardiorespiratory transition from fetus to newborn. Stevenson DK,  Frankel LR, Benitz WE.  J Perinatol.  1987; 7 (3): 221-5
• A technique for the administration of ribavirin to mechanically ventilated infants with severe respiratory syncytial virus infection. Frankel LR,  Wilson CW, Demers RR, Parker JR, Lewiston NJ, Stevenson DK, Smith DW.  Crit Care Med.  1987; 15 (11): 1051-4
• Metabolic emergencies of the newborn: hypoxemia and hypoglycemia. Frankel L,  Stevenson DK.  Compr Ther.  1987; 13 (10): 14-9