Key Documents

David Cornfield

Professor, Pediatrics - Pulmonary Medicine
Member, Cancer Center

Contact Information

Clinical Offices

Respiratory Specialties and ENT 730 Welch Rd 1st Floor Palo Alto, CA 94304
Telephone Work (650) 497-8841 Fax (650) 497-8791

Clinical Focus

Pediatric Pulmonary
Pulmonary Medicine/Cystic Fibrosis, Pediatric

Professional Education

Board Certification: Pediatric Pulmonary, American Board of Pediatrics (1994)
Board Certification: Pediatric Critical Care Medicine, American Board of Pediatrics (1996)
Children's Hospital-Denver (1993) CO
Children's Mercy Hospital (1989) MO
Children's Mercy Hospital (1987) MO
University of Wisconsin Medical School (1986) WI

Clinical Trials

Chronic Pulmonary Disease Database Recruiting
#5901 Primary Ciliary Dyskinesia Study Recruiting
#5902 Rare Genetic Disorders Study Recruiting
Cystic Fibrosis Registry Recruiting
Long term (12-24 hrs) infusion of nitroprusside (SNP) in pediatric patients to study the tolerability, safety, and pharmacodynamics of SNP. Recruiting

Publications

Developmental regulation of hypoxia-inducible factor 1 and prolyl-hydroxylases in pulmonary vascular smooth muscle cells. Resnik ER, Herron JM, Lyu SC, Cornfield DN. Proc Natl Acad Sci U S A. 2007; 104 (47): 18789-94
Lung specific developmental expression of the Xenopus laevis surfactant protein C and B genes. Hyatt BA, Resnik ER, Johnson NS, Lohr JL, Cornfield DN. Gene Expr Patterns. 2007; 7 (1-2): 8-14
Chronic intrauterine pulmonary hypertension increases capacitative calcium entry in fetal pulmonary artery smooth muscle cells. Resnik ER, Keck M, Sukovich DJ, Herron JM, Cornfield DN. Am J Physiol Lung Cell Mol Physiol. 2007; 292 (4): L953-9
Case-series of nurse-administered nitrous oxide for urinary catheterization in children. Zier JL, Drake GJ, McCormick PC, Clinch KM, Cornfield DN. Anesth Analg. 2007; 104 (4): 876-9
The unexpected effect of cyclosporin A on CD56+CD16- and CD56+CD16+ natural killer cell subpopulations. Wang H, Grzywacz B, Sukovich D, McCullar V, Cao Q, Lee AB, Blazar BR, Cornfield DN, Miller JS, Verneris MR. Blood. 2007; 110 (5): 1530-9
Wnt5a is required for cardiac outflow tract septation in mice. Schleiffarth JR, Person AD, Martinsen BJ, Sukovich DJ, Neumann A, Baker CV, Lohr JL, Cornfield DN, Ekker SC, Petryk A. Pediatr Res. 2007; 61 (4): 386-91
Chronic intrauterine pulmonary hypertension selectively modifies pulmonary artery smooth muscle cell gene expression. Resnik E, Herron J, Keck M, Sukovich D, Linden B, Cornfield DN. Am J Physiol Lung Cell Mol Physiol. 2006; 290 (3): L426-33
Oxygen tension modulates the expression of pulmonary vascular BKCa channel alpha- and beta-subunits. Resnik E, Herron J, Fu R, Ivy DD, Cornfield DN. Am J Physiol Lung Cell Mol Physiol. 2006; 290 (4): L761-L768
Inflammatory cytokines and the development of pulmonary complications after allogeneic hematopoietic cell transplantation in patients with inherited metabolic storage disorders. Kharbanda S, Panoskaltsis-Mortari A, Haddad IY, Blazar BR, Orchard PJ, Cornfield DN, Grewal SS, Peters C, Regelmann WE, Milla CE, Baker KS. Biol Blood Marrow Transplant. 2006; 12 (4): 430-7
Acute normoxia increases fetal pulmonary artery endothelial cell cytosolic Ca2+ via Ca2+-induced Ca2+ release. Tirosh R, Resnik ER, Herron J, Sukovich DJ, Hong Z, Weir EK, Cornfield DN. Pediatr Res. 2006; 60 (3): 258-63
Natural history of pulmonary complications in children after bone marrow transplantation. Eikenberry M, Bartakova H, Defor T, Haddad IY, Ramsay NK, Blazar BR, Milla CE, Cornfield DN. Biol Blood Marrow Transplant. 2005; 11 (1): 56-64
Oxygen increases ductus arteriosus smooth muscle cytosolic calcium via release of calcium from inositol triphosphate-sensitive stores. Keck M, Resnik E, Linden B, Anderson F, Sukovich DJ, Herron J, Cornfield DN. Am J Physiol Lung Cell Mol Physiol. 2005; 288 (5): L917-23
Extubation failure in pediatric intensive care incidence and outcomes. Baisch SD, Wheeler WB, Kurachek SC, Cornfield DN. Pediatr Crit Care Med. 2005; 6 (3): 312-8
Myeloperoxidase deficiency enhances inflammation after allogeneic marrow transplantation. Milla C, Yang S, Cornfield DN, Brennan ML, Hazen SL, Panoskaltsis-Mortari A, Blazar BR, Haddad IY. Am J Physiol Lung Cell Mol Physiol. 2004; 287 (4): L706-14
Safety of inhaled nitric oxide after lung transplantation. Cornfield DN, Milla CE, Haddad IY, Barbato JE, Park SJ. J Heart Lung Transplant. 2003; 22 (8): 903-7
Chronic intrauterine pulmonary hypertension compromises fetal pulmonary artery smooth muscle cell O2 sensing. Linden BC, Resnik ER, Hendrickson KJ, Herron JM, O'Connor TJ, Cornfield DN. Am J Physiol Lung Cell Mol Physiol. 2003; 285 (6): L1354-61
A rose by any other name is yet a rose: acute respiratory failure in children. Cornfield DN, Haddad IY. Am J Respir Crit Care Med. 2003; 168 (3): 268-9
Interactive effects of high-frequency oscillatory ventilation and inhaled nitric oxide in acute hypoxemic respiratory failure in pediatrics. Dobyns EL, Anas NG, Fortenberry JD, Deshpande J, Cornfield DN, Tasker RC, Liu P, Eells PL, Griebel J, Kinsella JP, Abman SH. Crit Care Med. 2002; 30 (11): 2425-9
Contribution of the K(Ca) channel to membrane potential and O2 sensitivity is decreased in an ovine PPHN model. Olschewski A, Hong Z, Linden BC, Porter VA, Weir EK, Cornfield DN. Am J Physiol Lung Cell Mol Physiol. 2002; 283 (5): L1103-9
Pulmonary vascular K+ channel expression and vasoreactivity in a model of congenital heart disease. Cornfield DN, Resnik ER, Herron JM, Reinhartz O, Fineman JR. Am J Physiol Lung Cell Mol Physiol. 2002; 283 (6): L1210-9
Continuous propofol infusion in 142 critically ill children. Cornfield DN, Tegtmeyer K, Nelson MD, Milla CE, Sweeney M. Pediatrics. 2002; 110 (6): 1177-81
A beta-peptides enhance vasoconstriction in cerebral circulation. Niwa K, Porter VA, Kazama K, Cornfield D, Carlson GA, Iadecola C. Am J Physiol Heart Circ Physiol. 2001; 281 (6): H2417-24
Polycyclic aromatic hydrocarbon diol epoxides increase cytosolic Ca(2+) of airway epithelial cells. Jyonouchi H, Sun S, Porter VA, Cornfield DN. Am J Respir Cell Mol Biol. 2001; 25 (1): 78-83
Pulmonary vascular response to normoxia and K(Ca) channel activity is developmentally regulated. Rhodes MT, Porter VA, Saqueton CB, Herron JM, Resnik ER, Cornfield DN. Am J Physiol Lung Cell Mol Physiol. 2001; 280 (6): L1250-7
Oxygen-induced fetal pulmonary vasodilation is mediated by intracellular calcium activation of K(Ca) channels. Porter VA, Rhodes MT, Reeve HL, Cornfield DN. Am J Physiol Lung Cell Mol Physiol. 2001; 281 (6): L1379-85
Effects of oxidant stress on inflammation and survival of iNOS knockout mice after marrow transplantation. Yang S, Porter VA, Cornfield DN, Milla C, Panoskaltsis-Mortari A, Blazar BR, Haddad IY. Am J Physiol Lung Cell Mol Physiol. 2001; 281 (4): L922-30
Ca(2+)-activated K(+) channels modulate basal and E(2)beta-induced rises in uterine blood flow in ovine pregnancy. Rosenfeld CR, Cornfield DN, Roy T. Am J Physiol Heart Circ Physiol. 2001; 281 (1): H422-31
Chronic intrauterine pulmonary hypertension decreases calcium-sensitive potassium channel mRNA expression. Cornfield DN, Resnik ER, Herron JM, Abman SH. Am J Physiol Lung Cell Mol Physiol. 2000; 279 (5): L857-62
Voltage-gated K(+)-channel activity in ovine pulmonary vasculature is developmentally regulated. Cornfield DN, Saqueton CB, Porter VA, Herron J, Resnik E, Haddad IY, Reeve HL. Am J Physiol Lung Cell Mol Physiol. 2000; 278 (6): L1297-304
Fetal rabbit pulmonary artery smooth muscle cell response to ryanodine is developmentally regulated. Porter VA, Reeve HL, Cornfield DN. Am J Physiol Lung Cell Mol Physiol. 2000; 279 (4): L751-7
Interactions of keratinocyte growth factor with a nitrating species after marrow transplantation in mice. Haddad IY, Panoskaltsis-Mortari A, Ingbar DH, Resnik ER, Yang S, Farrell CL, Lacey DL, Cornfield DN, Blazar BR. Am J Physiol. 1999; 277 (2 Pt 1): L391-400
Aerosol delivery of diethylenetriamine/nitric oxide, a nitric oxide adduct, causes selective pulmonary vasodilation in perinatal lambs. Cornfield DN, Martin EB, Hampl V, Archer SL. J Lab Clin Med. 1999; 134 (4): 419-25
Randomized, controlled trial of low-dose inhaled nitric oxide in the treatment of term and near-term infants with respiratory failure and pulmonary hypertension. Cornfield DN, Maynard RC, deRegnier RA, Guiang SF, Barbato JE, Milla CE. Pediatrics. 1999; 104 (5 Pt 1): 1089-94
NO causes perinatal pulmonary vasodilation through K+-channel activation and intracellular Ca2+ release. Saqueton CB, Miller RB, Porter VA, Milla CE, Cornfield DN. Am J Physiol. 1999; 276 (6 Pt 1): L925-32
K+-channel blockade inhibits shear stress-induced pulmonary vasodilation in the ovine fetus. Storme L, Rairigh RL, Parker TA, Cornfield DN, Kinsella JP, Abman SH. Am J Physiol. 1999; 276 (2 Pt 1): L220-8
Multicenter randomized controlled trial of the effects of inhaled nitric oxide therapy on gas exchange in children with acute hypoxemic respiratory failure. Dobyns EL, Cornfield DN, Anas NG, Fortenberry JD, Tasker RC, Lynch A, Liu P, Eells PL, Griebel J, Baier M, Kinsella JP, Abman SH. J Pediatr. 1999; 134 (4): 406-12
Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial. Kinsella JP, Walsh WF, Bose CL, Gerstmann DR, Labella JJ, Sardesai S, Walsh-Sukys MC, McCaffrey MJ, Cornfield DN, Bhutani VK, Cutter GR, Baier M, Abman SH. Lancet. 1999; 354 (9184): 1061-5
A maturational shift in pulmonary K+ channels, from Ca2+ sensitive to voltage dependent. Reeve HL, Weir EK, Archer SL, Cornfield DN. Am J Physiol. 1998; 275 (6 Pt 1): L1019-25
Effects of inhaled nitric oxide and oxygen in high-altitude pulmonary edema. Anand IS, Prasad BA, Chugh SS, Rao KR, Cornfield DN, Milla CE, Singh N, Singh S, Selvamurthy W. Circulation. 1998; 98 (22): 2441-5
Diversity of response in vascular smooth muscle cells to changes in oxygen tension. Weir EK, Reeve HL, Cornfield DN, Tristani-Firouzi M, Peterson DA, Archer SL. Kidney Int. 1997; 51 (2): 462-6
Inhalational nitric oxide in pulmonary parenchymal and vascular disease. Cornfield DN, Abman SH. J Lab Clin Med. 1996; 127 (6): 530-9
Ventilation-induced pulmonary vasodilation at birth is modulated by potassium channel activity. Tristani-Firouzi M, Martin EB, Tolarova S, Weir EK, Archer SL, Cornfield DN. Am J Physiol. 1996; 271 (6 Pt 2): H2353-9
Oxygen causes fetal pulmonary vasodilation through activation of a calcium-dependent potassium channel. Cornfield DN, Reeve HL, Tolarova S, Weir EK, Archer S. Proc Natl Acad Sci U S A. 1996; 93 (15): 8089-94
Hypoxia potentiates nitric oxide synthesis and transiently increases cytosolic calcium levels in pulmonary artery endothelial cells. Hampl V, Cornfield DN, Cowan NJ, Archer SL. Eur Respir J. 1995; 8 (4): 515-22
Ca(2+)-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function. Stevens T, Nakahashi Y, Cornfield DN, McMurtry IF, Cooper DM, Rodman DM. Proc Natl Acad Sci U S A. 1995; 92 (7): 2696-700
Acute reductions in PO2 depolarize pulmonary artery endothelial cells and decrease [Ca2+]i. Stevens T, Cornfield DN, McMurtry IF, Rodman DM. Am J Physiol. 1994; 266 (4 Pt 2): H1416-21
Acute hypoxia causes membrane depolarization and calcium influx in fetal pulmonary artery smooth muscle cells. Cornfield DN, Stevens T, McMurtry IF, Abman SH, Rodman DM. Am J Physiol. 1994; 266 (4 Pt 1): L469-75
Effects of oxygen and exogenous L-arginine on EDRF activity in fetal pulmonary circulation. McQueston JA, Cornfield DN, McMurtry IF, Abman SH. Am J Physiol. 1993; 264 (3 Pt 2): H865-71
Acute hypoxia increases cytosolic calcium in fetal pulmonary artery smooth muscle cells. Cornfield DN, Stevens T, McMurtry IF, Abman SH, Rodman DM. Am J Physiol. 1993; 265 (1 Pt 1): L53-6
Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus. Cornfield DN, Chatfield BA, McQueston JA, McMurtry IF, Abman SH. Am J Physiol. 1992; 262 (5 Pt 2): H1474-81
Role of ATP-sensitive potassium channels in ovine fetal pulmonary vascular tone. Cornfield DN, McQueston JA, McMurtry IF, Rodman DM, Abman SH. Am J Physiol. 1992; 263 (5 Pt 2): H1363-8